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Clinical research

Clinical research studies drugs, biological materials and medical devices in humans, evaluating possible beneficial effects as well as their safety and efficacy.

This kind of research is based on clinical trials, the results of which in their turn provide a great deal of support for evidence-based medicine.

In the last twenty years, the contribution of private capital, mostly originating from the pharmaceutical and medical device industry, has contributed significantly to an increase in the funding available for clinical research. At the same time, however, there has also been growing suspicion concerning the close relationship that has developed between some physicians who participate in clinical trials and the sponsoring companies.

There is a wide recognition that it is time for regulatory authorities, research institutes and scientific societies to become more sensitive to the pitfalls of such connections.

 

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  1. Assali A, Vaduganathan M, Vaknin-Assa H et al. Comparison of Late (3-Year) Registry Data Outcomes Using Bare Metal Versus Drug-Eluting Stents for Treating ST-Segment Elevation Acute Myocardial Infarctions. Am. J. Cardiol. 2012; 109:1563-1568 … more More
  2. Martinoni A, De Servi S, Politi A et al. Defining high-risk patients with ST-segment elevation acute myocardial infarction undergoing primary percutaneous coronary intervention: A comparison among different scoring systems and clinical definitions. Int. J. Cardiol. 2012; 157:207-211 … more More
  3. Schirmer SH, Degen A, Baumhäkel M et al. Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis. Eur Heart J 2012; 33: 1223-1231 … more More
  4. Patel VB, Bodiga S, Basu R et al. Loss of Angiotensin-Converting Enzyme-2 Exacerbates Diabetic Cardiovascular Complications and Leads to Systolic and Vascular Dysfunction: A Critical Role of the Angiotensin II/AT1 Receptor Axis. Circulation Research 2012;110 1322-1335 … more More
  5. Aversano T., Lemmon C.C., Liu L. Outcomes of PCI at hospitals with or without On-Site Cardiac Surgery. N Engl J Med 2012; 366:1792-1802 … more More
  6. Selker HP, Beshansky JR, Sheehan PR et al. Out-of-Hospital Administration of Intravenous Glucose-Insulin-Potassium in Patients With Suspected Acute Coronary Syndromes: The IMMEDIATE Randomized Controlled Trial. JAMA 2012;307(18):1925-1933 … more More
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  8. Berkowitch A, Kuniss M, Greiss H et al. Impact of Impaired Renal Function and Metabolic Syndrome on the Recurrence of Atrial Fibrillation after Catheter Ablation: A Long Term Follow-Up. PACE 2012; 35:532–543 … more More
  9. McEntegart MB, Kirtane AJ, Cristea E et al. Intraprocedural Thrombotic Events During Percutaneous Coronary Intervention in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes Are Associated With Adverse Outcomes: Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trial. J Am Coll Cardiol 2012;59: 1745-1751 … more More
  10. Murtagh G, Dawkins IR, O'Connell R et al. Screening to prevent heart failure (STOP-HF): expanding the focus beyond asymptomatic left ventricular systolic dysfunction. Eur J Heart Fail 2012; 14: 480-486 … more More

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